Publications by authors named "K P Flint"
Continuous glucose monitors (CGM) provide valuable insights about glycemic control that aid in diabetes management. However, interpreting metrics and charts and synthesizing them into linguistic summaries is often non-trivial for patients and providers. The advent of large language models (LLMs) has enabled real-time text generation and summarization of medical data.
View Article and Find Full Text PDFObjective: To examine the social determinants of early childhood caries (ECC), one of the greatest public health risks affecting children, and examine alternative pathways of influence.
Methods: A physically healthy, socio-demographically high-risk sample of initially caries-free children, aged 1-4 years, was prospectively studied for 2 years. At 6-month intervals, assessments were made of caries presence from a standard dental exam; oral microbiology was assayed from saliva samples; oral hygiene behaviors and psychological and psychosocial risk exposure were derived from interviews and questionnaires.
Following acute viral infection, naïve CD4+ T cells differentiate into T follicular helper (Tfh) and T helper 1 (Th1) cells that generate long-lived memory cells. However, it is unclear how memory Tfh and Th1 cells maintain their lineage commitment. Here we demonstrate that Tfh and Th1 lineages acquire distinct DNA methylation programs that are preserved into memory.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the connection between CMV infection and Th17 cells in kidney transplant recipients, finding that both factors independently raise the risk of late allograft loss.
- - Researchers observed that CMV-specific Th17 cells were present in blood samples and expanded during CMV reactivation, showing distinct characteristics compared to general Th17 cells.
- - The findings suggest that CMV-induced Th17 cells might play a role in causing inflammation that can lead to damage in transplanted kidneys, highlighting a possible pathway for allograft injury.
Background: Few randomized clinical trials test the effect of interventions on heart failure caregiver well-being.
Objective: The aim of this study was to determine the effect of a patient-focused symptom and psychosocial collaborative care intervention (Collaborative Care to Alleviate Symptoms and Adjust to Illness) on heart failure caregiver depression, burden, and benefit-finding.
Methods: A sequential explanatory mixed-method design was used in the context of a multisite, randomized clinical trial.