Antibodies to reticulin were found in 33% of coeliac patients on a normal diet. These antibodies were found in only 11% of coeliac patients on a gluten-free diet. In patients with dermatitis herpitiformis, 12% had these antibodies, whereas the highest frequency in the other diseases studied (Crohn's disease, ulcerative colitis, cystic fibrosis and `recurrent diarrhoea') was 7% (compared to 2% in healthy controls).
View Article and Find Full Text PDFArch Dermatol Res (1975)
December 1977
The univolved skin of 10 patients with dermatitis herpetiformis (DH) was examined for the presence of gluten antigens with the immunofluorescence technique using a rabbit anti-gliadin antiserum, human antibodies to wheat and to reticulin conjugated to fluorescein-isothiocyanate (FITC) and class-specific anti-human IgA immunoglobulin. In all patients, IgA deposits were found in the tips of the dermal papillae of the uninvolved skin. With the anti-wheat and anti-reticulin conjugates, as well as with the rabbit anti-gliadin antiserum, no specific immunofluorescence was observed in any of the skin specimens.
View Article and Find Full Text PDFA simple method of detecting gluten antibodies in serum is described. Cryostat sections of wheat grains proved to be an excellent substrate in the immunofluorescence technique. Rabbit antisera to gliadin and alpha-gliadin, and high percentage of sera from patients with gluten-induced enteropathy had antibodies that reacted with an internal structure of wheat grains.
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