Chronic head-down-tilt sleeping as physiological regulator of bone remodelling during diminished muscular activity in humans.

Objectives: Head-down-tilt (HDT) sleeping with periodic fluid redistribution (PFR) assumes a significant importance by the possibility of regulating bone remodelling. We hypothesized that HDT sleeping with chronic PFR which expands fluid volume would contribute to and/or increase bone formation. Therefore, we studied the potential benefits of osteogenesis with HDT sleeping of chronic PFR during diminished muscular activity (hypokinesia; HK).

Bone density benefits with periodic fluid redistribution during diminished muscular activity in humans.

Objective: Bone loss is an established reaction to diminished muscular activity (Hypokinesia; HK). It has been assumed that periodic fluid redistribution (PFR) could contribute to vascular volume. The fluid volume expansion would then increase tissue perfusion.

Potential benefits of potassium deposition with periodic fluid redistribution using periodic head down tilt during diminished muscular activity.

Objective: Fluid redistribution (FR) is an important cornerstone in treating diseases. Findings of FR with periodic head down tilt (PHDT) had sparked renewed interest in treating electrolyte disturbances. Therefore this study aimed to determine the potential benefits of potassium (K+) deposition with periodic FR by PHDT during diminished muscular activity (hypokinesia; HK).

Potassium deposition during and after hypokinesia in potassium supplemented and unsupplemented rats.

The aim of this study was to determine that hypokinesia (restricted motor activity) could increase potassium (K+) losses with decreased tissue K+ content showing decreased K+ deposition. To this end, measurements were made of K+absorption, tissue K+ content, plasma K+ levels, fecal and urinary K+ excretion during and after hypokinesia (HK) with and without K+ supplementation. Studies conducted on male Wistar rats during a pre-hypokinetic period, a hypokinetic period and a post-hypokinetic period.

Nuclear size measurements in collecting tubules of the rat kidney in establishing the effect of hypokinesia on the kidney morphology.

Background: Hypokinesia (reduced motor activity) induces significant tissue morphological changes, however, it is not known if hypokinesia (HK) could contribute to morphological changes in the kidney. Measuring the nuclear size in the inner medullary collecting ducts on the kidney of rats the aim of this investigation was to disclose kidney morphological changes during prolonged HK.

Methods: Studies were done on 192 13-week-old male rats (370 to 390 g) during 15 days pre-HK period and 90 days HK period.