Publications by authors named "K P C Kuypers"
Rationale: Despite the growing scientific interest on mitragynine, the primary alkaloid in kratom (Mitragyna Speciosa), there is a lack of clinical trials in humans.
Objectives: This phase 1 study aimed to evaluate mitragynine's safety profile and acute effects on subjective drug experience, neurocognition, and pain tolerance.
Methods: A placebo-controlled, single-blind, within-subjects study was conducted in two parts.
3-Methylmethcathinone (3-MMC) is a designer drug that belongs to the group of synthetic cathinones. The compound has been scheduled in many jurisdictions because of public health concerns associated with excessive use. To date, there are no clinical studies that have evaluated the risk profile of 3-MMC in the recreational range of low to moderate doses.
View Article and Find Full Text PDFConventional treatments offered by healthcare providers for adult ADHD include pharmacological and non-pharmacological approaches or a combination of both. Both treatment types may have downsides like side effects or low efficacy, potentially leading to treatment dissatisfaction. Also, adults with ADHD explore non-prescribed, complementary and/or alternative medicine (CAM) on their initiative, including substances such as dietary supplements and activities such as physical exercise.
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- Chorioamnionitis (HCA) and funisitis (FUN) are linked to preterm birth, and their combined effects can negatively influence an infant's respiratory drive after birth.* -
- A study involving 186 infants found that those with HCA and FUN had significantly lower gestational ages and birthweights compared to those without these conditions.* -
- While HCA and FUN were associated with reduced breathing effort in the first five minutes of life, subclinical HCA and FUN showed no significant impact on breathing metrics.*
Article Synopsis
- Microdosing psychedelics, particularly LSD, is gaining popularity for potential mental health benefits, but studies show mixed results, possibly due to individual differences in reactions.
- A study with 53 healthy participants tested low doses of LSD (15 mcg) and a placebo, measuring arousal, attention, and memory through various neurophysiological assessments over two weeks.
- Results indicated that LSD increased arousal and attention mainly in those with lower baseline states while inhibiting memory performance in high achievers; effects were still noticeable a week after treatment, suggesting lasting changes.