Analysis of long-term spatio-temporal wetland change reveals the complex nature of habitat alterations - A case study from the Czech Republic 1842-2017.

Wetlands fulfil a number of functions in the landscape, especially non-productive ones. Information on landscape and biotope changes is important not only from a theoretical point of view for understanding the forces and pressures that cause changes in the landscape, but also from a practical point of view, as we can take inspiration from history when planning the landscape. The main goal of this study is to analyse the dynamics and trajectories of changes in wetlands, including testing the influence of the main natural conditions (climate, geomorphology) on their changes, for a large area of 141 cadastral territories (1315 km), which will allow the results to be sufficiently generalized.

Prostaglandins and cannabis--XIII. Cannabinoid-induced elevation of lipoxygenase products in mouse peritoneal macrophages.

The phospholipases controlling the release of arachidonic acid in mouse peritoneal macrophages have been shown to be stimulated by the natural psychoactive cannabinoids. A close correlation was observed between the potencies of these substances in elevating arachidonate levels in vitro and the reported activities in a behavioral assay in monkeys and in producing a "high" in humans. The order of activity with the macrophages was delta 1-tetrahydrocannabinol (delta 1-THC) greater than 7-OH-delta 1-THC greater than 6 alpha-OH-delta 1-THC greater than 6 beta-delta 1-THC much greater than delta 6-THC-7-oic acid.

Prostaglandins and cannabis. XII. The effect of cannabinoid structure on the synthesis of prostaglandins by human lung fibroblasts.

Earlier findings indicated that several other cannabinoids in addition to delta 1-tetrahydro-cannabinol (THC) were able to stimulate the synthesis of prostaglandins in cell culture systems. The present study was initiated to delineate the structural requirements for this effect within the cannabinoid series. Among the primary cannabinoids, we found that the trend was for more planar structures to show greater activity.