Publications by authors named "K Osada"
Background And Purpose: Although carbon-ion radiotherapy (CIRT) has led to good outcomes, controlling metastasis is still crucial for improving overall survival. This study aimed to evaluate the effectiveness of by two combinations, one of CIRT and anti-CTLA4 antibody, the other of CIRT and anti-PD-1 antibody, applied at different radiation doses for distal tumour and metastasis suppression.
Materials And Methods: Murine cancer cells (colon carcinoma Colon-26 cells for experiments and osteosarcoma LM8 cells for verification) were grafted into both sides of the hind legs of syngeneic mice.
Article Synopsis
- Dietary phytosterols are generally beneficial for reducing cholesterol, but their oxidized forms can be harmful, causing cytotoxicity and inflammation.
- The study focused on oxidized stigmasterol, a common phytosterol, and its impact on the antioxidant system in mice, revealing increased oxidized stigmasterol levels in the liver of mice that consumed it.
- Although dietary oxidized stigmasterol raised certain harmful indicators of oxidative stress in the liver, there was no lasting damage, as the body's antioxidant enzymes and glutathione reacted quickly to mitigate these effects.
Background: Treatment for osteochondritis dissecans (OCD) of the humeral capitellum has been predominantly guided by fragment stability and articular cartilage integrity. Nonoperative management is recommended for stable lesions, whereas surgical intervention is indicated for unstable lesions and those that fail nonoperative care. Several surgical options may be considered, although limited information is available regarding indications for specific surgical techniques and comparative postoperative results.
View Article and Find Full Text PDFArticle Synopsis
- Early life stress (ELS) in mice leads to cognitive issues and changes in dopamine receptor expression in the male offspring's anterior cingulate cortex (ACC).
- Fragmented maternal care during a critical neonatal period resulted in elevated D2R and suppressed D4R, impairing performance on visual attention tasks, but this could be reversed in adulthood through pharmacological interventions.
- ELS male mice also exhibited increased hypothalamic orexin and disrupted sleep patterns, pointing to sleep loss as a possible underlying factor for cognitive deficits, a correlation that extends to attention issues observed in children who experienced early adversity.
Many in vitro studies have revealed the toxic effects of oxidized phytosterols (OPSs); however, their effects on lipid metabolism are not well understood in vivo. Therefore, we examined the bioavailability of OPS and compared the effects of dietary phytosterols (PSs) or OPS on lipid metabolism in rats. OPS was detected in the plasma and liver of rats administered 50 mg of OPS for 3 days.
View Article and Find Full Text PDF