Publications by authors named "K Orlicka"
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View Article and Find Full Text PDFArticle Synopsis
- CD14+ mononuclear phagocytes (MNPs) and T cells are found in the colon of ulcerative colitis (UC) patients, influencing T cell responses through cytokines produced by MNPs.
- In the inflamed colon, a specific subpopulation of CD14+ MNPs that produce pro-inflammatory cytokines (CD163-) is linked to the development of various T helper cell responses, particularly Th17.
- The study suggests that CD163- monocyte-like MNPs enhance the frequency of IL-8-producing CD4+ T cells through cytokines like IL-1β and IL-12, highlighting their potential contribution to the mechanisms behind UC.
Inflammatory bowel diseases are associated with dysregulated immune responses in the intestinal tissue. Four molecularly identified macrophage subsets control immune homeostasis in healthy gut. However, the specific roles and transcriptomic profiles of the phenotypically heterogeneous CD14 macrophage-like population in inflamed gut remain to be investigated in Crohn's disease (CD).
View Article and Find Full Text PDFRecruitment of activated neutrophils correlates with disease severity in adult Crohn's disease.
Clin Exp Immunol
February 2019
Neutrophils are detected in inflamed colon in Crohn's disease (CD). However, whether the frequency and/or activation of circulating or gut tissue neutrophils correlate with endoscopic severity remains to be investigated. A cohort of 73 CD patients was prospectively enrolled according to endoscopic severity and treatment history.
View Article and Find Full Text PDFBackgound: Tobacco is one of the most significant risk factors for inflammatory bowel disease (IBD).
Goals: The main objective was to assess the knowledge of patients with IBD regarding the effects of tobacco on their disease. Secondary objectives were to determine the source of their knowledge, the influence of their knowledge on their intent to quit smoking, and the association between patients' characteristics and their knowledge.