Publications by authors named "K Orio"
Article Synopsis
- The smectite group of clay minerals, including montmorillonite, can delaminate into single layers in water due to osmotic swelling, facilitated by small alkaline cations like Na or Li.
- This study reveals that montmorillonite also exhibits osmotic swelling in mixed solvents of water with acetonitrile and 2-propanol, despite previous beliefs that inorganic interlayer cations hinder delamination in organic solvents.
- The research findings indicate that saWelling patterns vary based on the type of interlayer cations, with specific behaviors observed under different solvent conditions, confirmed through macroscopic observations, XRD patterns, and SEM imaging.
Objective: To estimate the population pharmacokinetic parameters of disopyramide using non-linear mixed effects modelling.
Method: A total of 148 serum levels from 109 patients (61 males and 48 females) receiving disopyramide were collected.
Results: The final pharmacokinetic model was Cl (L/h)=3.