Publications by authors named "K Okuno"
Article Synopsis
- The study focused on the effectiveness of oral appliance (OA) therapy for patients who couldn't continue with CPAP therapy for sleep apnea.
- Out of 81 patients, 60 continued using OA for more than a year, showing a significant reduction in apnea episodes.
- Awareness of OA's effectiveness after one month was identified as a key predictor for long-term adherence to OA therapy.
Background: Joint effusion at 3 months after anterior cruciate ligament (ACL) reconstruction is a risk factor for ACL reinjury. However, factors associated with joint effusion at 3 months postoperatively and the effect of joint effusion on subsequent quadriceps muscle strength and graft remodeling remain unknown.
Purposes: To identify factors associated with joint effusion and investigate the association between joint effusion and quadriceps muscle strength and graft remodeling in the postoperative period.
Article Synopsis
- Histone lactylation is a new epigenetic modification driven by lactate from glycolysis, which is often heightened in cancer, notably gastric cancer (GC), and is linked to poorer patient outcomes.
- In GC, increased levels of histone H3K18 lactylation correlate with worse prognosis, while SIRT1 plays a key role in regulating these levels by either promoting or diminishing H3K18la depending on its expression.
- Targeting the interplay between SIRT1, the lncRNA H19, and glycolysis presents a promising therapeutic approach for GC, showing significant anti-cancer effects while minimizing harm to normal cells.
Article Synopsis
- Juvenile xanthogranuloma (JXG) is a rare benign condition primarily affecting neonates and young children, often presenting as skin lesions, but intramuscular JXG is much less common, accounting for only 0.6% of cases.
- A case involving a 5-month-old girl showed a slow-growing lump in her left thigh, which was diagnosed as deep JXG after imaging, biopsy, and surgical resection.
- Histological findings revealed characteristics typical of JXG, and despite initial concerns about tumor margins, the patient has shown no signs of recurrence over 48 months post-surgery, highlighting the importance of proper diagnosis and monitoring.