Publications by authors named "K Ojala"
Clinicopathologic features and surgical management in vulvovaginal melanoma - A retrospective single-center study.
J Plast Reconstr Aesthet Surg
January 2025
Article Synopsis
- Vulvovaginal melanoma is a rare and aggressive form of cancer with low survival rates, reviewed in a study at Helsinki University Hospital over two decades.
- The majority of cases occurred in the vulva (86%), with surgery being the primary treatment method (86% of patients), but recurrences were common, particularly in distant sites.
- Key findings indicated that while wide local excision may be a viable treatment option, nodal status significantly impacts overall survival, highlighting the need for more research on lymph node evaluation in these patients.
Background: The role of eating habits in adolescent mental health has become a growing area of interest for researchers and health professionals. Recent studies suggest that healthy eating habits may play a role in the development and management of mental health. However, existing literature is largely based on clinical populations, and comparisons are challenged by sociocultural differences and methodological issues.
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- Chest masculinization is the most common surgery for transgender men, with new research using the BODY-Q Chest module showing high postoperative satisfaction and quality of life.
- Out of 220 patients surveyed, 123 responded, revealing good satisfaction scores of 76 for chest and 68 for nipple aesthetics, although overall health-related quality of life was lower than the age-standardized male population.
- The study found no significant differences in satisfaction based on surgical techniques, and there is a concerning link between a higher number of secondary surgeries and lower satisfaction scores, signaling a need for further investigation.
Objectives: Social media has become integrated into adolescents' lives and influences body image perceptions. Our study examined four patterns of social media use (SMU): non-active, active, intensive, and problematic. We hypothesised that intensive SMU and problematic SMU would be associated with negative body image (negative subjective body weight) and over/underestimated body weight congruence, compared to non-active and active SMU.
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- - Liposarcomas (LPSs) are complex tumors from fat tissue that lack specific treatments, prompting researchers to explore new therapy targets through RNA sequencing and bioinformatics analysis of clinical samples.
- - The study identified distinct gene expressions in various LPS subtypes and highlighted specific activated signaling pathways linked to each, such as hedgehog signaling in dedifferentiated LPS and insulin signaling in myxoid LPS.
- - A significant correlation was found between high expression of the PDE3A gene and myxoid LPS, revealing that PDE3A modulators could be effective treatments for this subtype, although further clinical development is essential.