Publications by authors named "K Ohnuma"
Gravity-driven microfluidic chips offer portability and flexibility in different settings because pumps and connecting tubes are unnecessary for driving fluid flow. In a previous study, human induced pluripotent stem cells were cultured using gravity-driven microfluidics, with the liquid flow rate regulated by a tilting table. However, instability in cell culture has been observed, occasionally leading to cell death owing to unknown causes.
View Article and Find Full Text PDFThe abuse of prohibited peptide-based drugs with a broad spectrum of chemical characteristics poses a significant concern for the horseracing industry. Recently, there has been a notable increase in positive cases of small-peptide drugs reported in equine and canine sports. In addition to small peptides, large peptides (over 2 kDa) with structural diversity have also entered the market in increasing numbers as drugs for humans and livestock.
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- - All 11 patients with bacteremia were treated with daptomycin and initially responded well, showing susceptibility to the drug.
- - During treatment, daptomycin nonsusceptibility developed in 36% of the patients.
- - Clinical failure occurred in 45% of the patients, highlighting significant challenges in effective treatment.
Glucose transporter 1 deficiency syndrome (GLUT1DS), caused by impaired glucose transport at the blood-brain barriers, leads to various central nervous system dysfunctions. A comprehensive understanding of the underlying disease pathogenesis is still lacking. In this study, we have generated GLUT1DS-specific human induced pluripotent stem cells (hiPSCs) derived from two patients.
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- CD26 is a T cell costimulatory molecule and its levels are usually increased in autoimmune diseases, but decreased in patients with systemic lupus erythematosus (SLE), indicating a unique aspect of SLE pathology.
- In this study, researchers analyzed CD26+ and CD26(-) T cell populations from SLE patients, finding an abnormal rise in CD26(-) T cells that display characteristics similar to natural killer T cells.
- The study suggests that evaluating CD26(-)CD28(-) T cell populations may help in understanding and classifying the complex nature of SLE, particularly since their levels can vary significantly even among inactive patients.