Publications by authors named "K Ohmura"

IgG4-related disease (IgG4-RD) is a systemic, immune-mediated, fibroinflammatory disorder that affects multiple organs. Histopathologically, the supportive findings of IgG4-RD include dense lymphocytic infiltrates, obliterative phlebitis, storiform fibrosis, and elevated numbers of IgG4-positive plasma cells. However, the presence of granulomatous inflammation is generally considered highly atypical, suggesting alternative diagnoses such as sarcoidosis and lymphoma.

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  • JAK inhibitors, used to treat rheumatoid arthritis, can increase the risk of herpes zoster, prompting the need for appropriate vaccination timing with the recombinant zoster vaccine (RZV).
  • The STOP HZ study aims to determine whether initiating tofacitinib at the first or second RZV vaccination affects patients' immune response (IgG titers and T cell response) and disease activity.
  • This multicenter, randomized study will recruit 60 patients and measure various treatment outcomes, all while conforming to ethical guidelines and requiring informed consent.
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Objective: Osteoporosis and osteopenia are significant concerns in rheumatoid arthritis (RA), predisposing patients to fragility fractures. While dual-energy X-ray absorptiometry (DXA) is the gold standard for bone mineral density (BMD) assessment, simpler screening tools are needed. This study aims to assess the correlation between the second metacarpal cortical index (2MCI) and BMD in RA patients, and to evaluate machine learning (ML) models utilizing 2MCI and clinical parameters for predicting osteoporosis/osteopenia presence and BMD.

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  • * Neoself-antigens, which are unusual self-targets, are presented on MHC-II when the invariant chain is absent, leading to the activation of autoreactive T cells in SLE.
  • * Research shows that these neoself-reactive T cells expand in SLE patients and can be activated by cells reactivated by the Epstein-Barr virus, indicating a significant relationship between viral infections and the development of lupus.
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