Publications by authors named "K Ofir"
Article Synopsis
- The study investigates the pregnancy outcomes of women with antiphospholipid syndrome (APS) and antiphospholipid antibodies (aPL) who have had five or more pregnancies (grand multiparity) and compares them to two control groups: those with fewer pregnancies and those without aPL/APS.
- Results showed that while most pregnancy-related parameters were similar across the groups, grand multiparity women with aPL/APS had higher rates of obstetric APS diagnosis, older maternal age, higher body mass index (BMI), more cases of polyhydramnios, and delivered larger babies.
- The conclusions suggest that the perinatal outcomes for grand multiparity women with aPL/APS are not worse than those of their counterparts
Objective: To assess the capacity of fetal pancreatic size, before standard blood glucose testing for screening and diagnosis, to predict maternal gestational diabetes mellitus (GDM).
Methods: This was a retrospective cohort study of low-risk pregnant women recruited during routine second-trimester fetal anatomical screening at 20-25 weeks' gestation at two ultrasound units in Israel between 2017 and 2020. The predictive performance of fetal pancreatic circumference ≥ 80 and ≥ 90 centiles and glucose challenge test (GCT) was examined for the outcome of GDM.
During pregnancy, fetal glucose production is suppressed, with rapid activation immediately postpartum. Fatty acid-binding protein 4 (FABP4) was recently demonstrated as a regulator of hepatic glucose production and systemic metabolism in animal models. Here, we studied the role of FABP4 in regulating neonatal glucose hemostasis.
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- A study on pregnant guinea pigs aimed to improve fetal growth by overexpressing VEGF (Vascular Endothelial Growth Factor) in the uterine arteries, drawing parallels to human placental function.
- Ad.VEGF-A treatment resulted in increased fetal weight and larger organ sizes compared to a control group treated with Ad.LacZ, indicating a positive effect on growth.
- The results showed that the treatment enhanced blood flow in the uterine artery and boosted VEGF levels in the target tissues, suggesting a potentially effective strategy for addressing fetal growth restriction.