Integration of clinical outcomes and molecular features in extramedullary disease in multiple myeloma.

Multiple myeloma (MM) remains incurable despite novel therapeutics. A major contributor to the development of relapsed/refractory and resistant MM is extraosseous extramedullary disease (EMD), whose molecular biology is still not fully understood. We analyzed 528 MM patients who presented to our institution between 2014 and 2021 and who had undergone molecular testing.

[Rehabilitation therapy for aquaporin-4 antibody positive neuromyelitis optica spectrum disorders].

Forty-five cases with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorders (NMOSD) who underwent convalescent rehabilitation were studied. After excluding three cases with recurrence during rehabilitation treatment, the Expanded Disability Status Scale of Kurtzke improved a median of 1 point. Corticosteroids were the most used disease-modifying drugs (DMDs).

BCR::ABL1-induced mitochondrial morphological alterations as a potential clinical biomarker in chronic myeloid leukemia.

The BCR::ABL1 oncogene plays a crucial role in the development of chronic myeloid leukemia (CML). Previous studies have investigated the involvement of mitochondrial dynamics in various cancers, revealing potential therapeutic strategies. However, the impact of BCR::ABL1 on mitochondrial dynamics remains unclear.

Clinical characteristics and results after conservative treatment or interfascicular neurolysis of 100 limbs with spontaneous anterior interosseous nerve palsy: A prospective Japanese multicenter study.

Background: Spontaneous anterior interosseous nerve (AIN) palsy is characterized by the sudden onset of upper limb pain followed by weakness of muscles mainly innervated by the AIN. Although this palsy is conventionally treated conservatively, interfascicular neurolysis to release hourglass-like fascicular constrictions has been recommended. The present study aimed to establish the clinical characteristics and treatment strategy for this condition.

Integrated radiation air dose rate maps over the 80 km radius of the Fukushima Daiichi Nuclear Power Plant and the entire Fukushima Prefecture during 2011-2022.

In this study, we created integrated radiation air dose rate maps in the Fukushima region during 2011-2022 using airborne, car-borne, and walk surveys and fixed-location measurements. We applied a Bayesian geostatistical method to the 80 km radius of the Fukushima Daiichi Nuclear Power Plant and the entire Fukushima Prefecture while considering the history of the evacuation zone lifting in Fukushima. The integrated maps in this study fixed the bias to underestimate the air dose rates in forest areas and created integrated maps with a wider area and time series than previous studies.