Publications by authors named "K O Pascoe"
While COVID-19 immunizations can improve outcomes from SARS-CoV-2, vaccine rates in the United States have been lowest among children under age 11 and among rural agricultural communities. This study examined factors influencing pediatric COVID-19 vaccine uptake among rural agricultural and predominantly Hispanic communities in Washington State. We conducted in-depth interviews with school district employees and students and held English and Spanish focus group discussions with parents, all of which were audio-recorded and transcribed.
View Article and Find Full Text PDFBackground: MAGNITUDE (NCT03748641) demonstrated favourable outcomes with niraparib plus abiraterone acetate plus prednisone (+AAP) versus placebo+AAP in patients with BRCA1/2-altered metastatic castration-resistant prostate cancer (mCRPC). Imbalances in prognostic variables were reported between arms, which impacts estimation of both the clinical benefit and cost‑effectiveness of niraparib+AAP for healthcare systems. A pre-specified multivariable analysis (MVA) demonstrated improved overall survival (OS) with niraparib+AAP.
View Article and Find Full Text PDFIntroduction: Poly(ADP-ribose) polymerase inhibitors (PARPi) are a novel option to treat patients with metastatic castration-resistant prostate cancer (mCRPC). Niraparib plus abiraterone acetate and prednisone (AAP) is indicated for BRCA1/2 mutation-positive mCRPC. Niraparib plus AAP demonstrated safety and efficacy in the phase 3 MAGNITUDE trial (NCT03748641).
View Article and Find Full Text PDFArticle Synopsis
- - A study analyzed the presence of SARS-CoV-2 in the feces of lactating women diagnosed with COVID-19 and their breastfed infants, focusing on potential associations with symptoms and fecal shedding.
- - Involving 57 maternal-infant pairs, the research found that SARS-CoV-2 RNA was present in 25% of mothers and 30% of infants, with fecal shedding lasting between 1-4 weeks.
- - Despite mothers experiencing various symptoms, the prevalence of symptoms in their infants was similar to healthy control infants, and there was no correlation between the fecal shedding frequency of mothers and their infants, although maternal fever increased the likelihood of infant fecal shedding.
Objectives: This study aimed to assess the prevalence of and factors correlated with accepting a pelvic examination under anesthesia (EUA) by learners at the time of surgical abortion.
Study Design: Retrospective chart review assessing the prevalence of and comparing factors associated with accepting EUA by learners at the time of abortion.
Results: Most (88%) of the 274 patients accepted EUA by learners.