Publications by authors named "K O McNerney"
This study presents an examination of the neural connectivity associated with processing speech in noisy environments, an ability that declines with age. We correlated subjects' speech-in-noise (SIN) ability with resting-state MRI scans and Fractional Anisotropy (FA) values from the auditory section of the corpus callosum, both with and without correcting for age. The results revealed that subjects who performed poorly on the right ear SIN test (QuickSIN, MedRx) had higher correlations between the primary auditory cortex and regions of the brain that process language.
View Article and Find Full Text PDFBackground: Cytokines are soluble signaling proteins that regulate inflammation and coordinate immune responses. Serum cytokine panels are increasingly used in medical practice, yet our understanding of cytokines as biomarkers for disease remains limited.
Objective: We sought to analyze real-world single-center use of a multiplexed cytokine panel, correlate its results with diagnosis and severity, and explore its use in pediatric practice.
Article Synopsis
- MCT8 deficiency is a rare, X-linked disorder caused by mutations affecting thyroid hormone transport, leading to severe developmental delays and motor disabilities due to insufficient thyroid hormone in the brain.
- Diagnosis and treatment of MCT8 deficiency face major challenges, including a lack of awareness among healthcare professionals, resulting in misdiagnoses and delays, as well as complex symptoms that may not surface until months after birth.
- Multidisciplinary care is essential for optimal patient support, and while there are no specific treatments available yet, early diagnosis can help improve access to supportive care and developing interventions to enhance the quality of life for patients and their families.
Background: The goal of this study was to assess the effect of donor type and pre-transplant immunotherapy (IST) on outcomes of hematopoietic stem cell transplantation (HSCT) for children and young adults with severe aplastic anemia (SAA).
Methods: This retrospective, multi-center study included 52 SAA patients, treated in 5 pediatric transplant programs in Florida, who received HSCT between 2010 and 2020 as the first- or second-line treatment.
Results: The median age at HSCT for all 52 patients was 15 years (range 1-25).