Publications by authors named "K O Learned"
Background And Purpose: Neoadjuvant BRAF-directed therapy and immunotherapy followed by surgery improves survival in patients with BRAF-mutant anaplastic thyroid carcinoma (ATC), more so in those who have complete ATC pathologic response. This study assesses the ability of FDG-PET to non-invasively detect residual high-risk pathologies including ATC and poorly differentiated thyroid carcinoma (PDTC) in the preoperative setting.
Materials And Methods: This retrospective, single-center study included consecutive BRAF-mutant ATC patients treated with at least 30 days of neoadjuvant BRAF-directed therapy and who underwent FDG-PET/CT within 30 days prior to surgery.
Article Synopsis
- * Fungal sinusitis is divided into invasive and noninvasive types, with CT being better for spotting bony damage and MRI more effective for assessing soft tissue involvement.
- * Early detection of invasive cases, especially in immunocompromised patients, is crucial for effective treatment, with specific radiologic signs aiding in diagnosis.
Advanced MRI-based neuroimaging techniques, such as perfusion and spectroscopy, have been increasingly incorporated into routine follow-up protocols in patients treated for high-grade glioma (HGG), to help differentiate tumor progression from treatment effect. However, these techniques' influence on clinical management remains poorly understood. The purpose of this article was to evaluate the impact of MRI-based advanced neuroimaging on clinical decision-making in patients with HGG after treatment.
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- BRAF/MEK inhibitors have significantly improved outcomes for patients with BRAF V600E-variant anaplastic thyroid carcinoma (BRAFv-ATC), which was previously considered untreatable.
- Given that anaplastic thyroid carcinoma is a highly aggressive cancer linked to high mortality, quick diagnosis and treatment are crucial for better patient survival.
- The FAST Consensus Statement stresses the need for early detection of the BRAF V600E variant and suggests streamlined treatment approaches to enhance patient care, addressing the recent advancements that still need to be reflected in clinical guidelines.
Background And Purpose: Parathyroid carcinoma is the rarest endocrine neoplasm with very few published data discussing its imaging appearance with primary focus on ultrasound imaging features. We present our 23 years institutional experience to highlight multimodality imaging evaluation at presentation and at recurrence.
Material And Methods: Retrospective chart review of clinical and pathological diagnosis of parathyroid carcinoma patients presented for initial or recurrent disease management at M.