Publications by authors named "K O Kurppa"

Objectives: Diagnosis of coeliac disease based on serology only has been allowed since 2018 in Finland for adults meeting specific criteria. We studied the patient experiences and perceptions of this novel diagnostic option.

Methods: Altogether 194 adult patients were questioned on socio-demographic and health-related characteristics, quality of life and various coeliac disease-related issues.

View Article and Find Full Text PDF

Season of birth, viral infections, HLA haplogenotypes and non-HLA variants are implicated in the development of celiac disease and celiac disease autoimmunity, suggesting a combined role of genes and environmental exposures. The aim of the study was to further decipher the biological pathways conveying the season of birth effect in celiac disease autoimmunity to gain novel insights into the early pathogenesis of celiac disease. Interactions between season of birth, genetics, and early-life environmental factors on the risk of celiac autoimmunity were investigated in the multicenter TEDDY birth cohort study.

View Article and Find Full Text PDF

Background And Aims: The environmental factors, apart from gluten ingestion predisposing to coeliac disease are poorly known. Smoking is associated with many immune-mediated diseases, but research on coeliac disease is scarce. This study aims to investigate how smoking affects the clinical presentation, presence of comorbidities and response to gluten-free diet in coeliac disease.

View Article and Find Full Text PDF
Article Synopsis
  • Odontogenic tumors (OGTs) are rare, and primary intraosseous carcinoma NOS (PIOC) is an even rarer subtype with a poor prognosis, characterized by unclear immunohistochemical features and pathogenesis.
  • A histopathological study of a PIOC case in the left mandible revealed a transition from an odontogenic keratocyst to carcinoma, with signs of malignant behavior such as invasive growth and specific biomarker alterations.
  • Immunohistochemical analysis indicated increased levels of certain proteins (ARL4C, YAP) in the tumor, activation of Wnt/β-catenin signaling, and suggested that varied intracellular signaling pathways might play a role in the disease's pathogenesis.
View Article and Find Full Text PDF

Despite clinical benefits of tyrosine kinase inhibitors (TKIs) in cancer, most tumors can reactivate proliferation under TKI therapy. Here we present transcriptional profiling of HER2+ breast cancer cells transitioning from dormant drug tolerant cells to re-proliferating cells under continuous HER2 inhibitor (HER2i) therapy. Focusing on phosphatases, expression of dual-specificity phosphatase DUSP6 was found inhibited in dormant cells, but strongly induced upon regrowth.

View Article and Find Full Text PDF