Long-term tropospheric ozone pollution disrupts plant-microbe-soil interactions in the agroecosystem.

Tropospheric ozone (O ) threatens agroecosystems, yet its long-term effects on intricate plant-microbe-soil interactions remain overlooked. This study employed two soybean genotypes of contrasting O -sensitivity grown in field plots exposed elevated O (eO ) and evaluated cause-effect relationships with their associated soil microbiomes and soil quality. Results revealed long-term eO effects on belowground soil microbiomes and soil health surpass damage visible on plants.

Wnt10b protects cardiomyocytes against doxorubicin-induced cell death via MAPK modulation.

Background: Doxorubicin, an anthracycline chemotherapeutic known to incur heart damage, decreases heart function in up to 11% of patients. Recent investigations have implicated the Wnt signaling cascade as a key modulator of cardiac tissue repair after myocardial infarction. Wnt upregulation in murine models resulted in stimulation of angiogenesis and suppression of fibrosis after ischemic insult.

The interaction of O and CO concentration, exposure timing and duration on stem rust severity on winter wheat variety 'Coker 9553'.

Wheat rusts, elevated ozone (O), and carbon dioxide (CO) are simultaneously impacting wheat production worldwide, but their interactions are not well understood. This study investigated whether near-ambient O is suppressive or conducive to stem rust (Sr) of wheat, considering the interactions with ambient and elevated CO. Winter wheat variety 'Coker 9553' (Sr-susceptible; O sensitive) was inoculated with Sr (race QFCSC) following pre-treatment with four different concentrations of O (CF, 50, 70, and 90 ppbv) at ambient CO levels.

A Rapid Alkalinization Factor-like Peptide EaF82 Impairs Tapetum Degeneration during Pollen Development through Induced ATP Deficiency.

In plants, the timely degeneration of tapetal cells is essential for providing nutrients and other substances to support pollen development. Rapid alkalinization factors (RALFs) are small, cysteine-rich peptides known to be involved in various aspects of plant development and growth, as well as defense against biotic and abiotic stresses. However, the functions of most of them remain unknown, while no RALF has been reported to involve tapetum degeneration.

Modulating pentenoate-functionalized hyaluronic acid hydrogel network properties for meniscal fibrochondrocyte mechanotransduction.

Knee meniscus tears are one of the most common musculoskeletal injuries. While meniscus replacements using allografts or biomaterial-based scaffolds are available, these treatments rarely result in integrated, functional tissue. Understanding mechanotransducive signaling cues that promote a meniscal cell regenerative phenotype is critical to developing therapies that promote tissue regeneration rather than fibrosis after injury.