Publications by authors named "K Nowicki-Osuch"
Article Synopsis
- This study investigates the microbiomes of the oral cavity, esophagus, and stomach using different sampling methods in patients with varying risks for esophageal cancer, specifically esophageal squamous cell carcinoma (ESCC).
- Researchers analyzed samples from 11 patients with pre-cancerous conditions, 21 head and neck cancer survivors, and 40 individuals with functional dyspeptic symptoms, using advanced genetic sequencing techniques.
- Findings indicate significant differences in microbial diversity and composition across the different patient groups, particularly between functional dyspepsia patients and cancer survivors, but note that the relationship between microbiota changes and treatments for head and neck cancer is still unclear.
Background: While p53 mutations occur early in Barrett's oesophagus (BE) progression to oesophageal adenocarcinoma (EAC), their role in gastric cardia stem cells remains unclear.
Objective: This study investigates the impact of p53 mutation on the fate and function of cardia progenitor cells in BE to EAC progression, particularly under the duress of chronic injury.
Design: We used a BE mouse model (L2-IL1β) harbouring a mutation (R172H) to study the effects of p53 on Cck2r cardia progenitor cells.
Esophageal adenocarcinoma is a prominent example of cancer characterized by frequent amplifications in oncogenes. However, the mechanisms leading to amplicons that involve breakage-fusion-bridge cycles and extrachromosomal DNA are poorly understood. Here, we use 710 esophageal adenocarcinoma cases with matched samples and patient-derived organoids to disentangle complex amplicons and their associated mechanisms.
View Article and Find Full Text PDFUnlabelled: Intestinal metaplasia in the esophagus (Barrett's esophagus IM, or BE-IM) and stomach (GIM) are considered precursors for esophageal and gastric adenocarcinoma, respectively. We hypothesize that BE-IM and GIM follow parallel developmental trajectories in response to differing inflammatory insults. Here, we construct a single-cell RNA-sequencing atlas, supported by protein expression studies, of the entire gastrointestinal tract spanning physiologically normal and pathologic states including gastric metaplasia in the esophagus (E-GM), BE-IM, atrophic gastritis, and GIM.
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