Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations.

The prevalence and nature of somatic copy number alterations (CNAs) in breast epithelium and their role in tumor initiation and evolution remain poorly understood. Using single-cell DNA sequencing (49,238 cells) of epithelium from BRCA1 and BRCA2 carriers or wild-type individuals, we identified recurrent CNAs (for example, 1q-gain and 7q, 10q, 16q and 22q-loss) that are present in a rare population of cells across almost all samples (n = 28). In BRCA1/BRCA2 carriers, these occur before loss of heterozygosity (LOH) of wild-type alleles.

The moa footprints from the Pliocene - early Pleistocene of Kyeburn, Otago, New Zealand.

In March, 2019, a trackway of seven footprints was found at a riverbank outcrop of Maniototo Conglomerate Formation in the Kyeburn River, Central Otago, South Island, New Zealand. In this study, we describe this first known occurrence of moa (Dinornithiformes) footprints to be found and recovered in Te Waipounamu/South Island. Footprints of the trackway were ∼46 mm deep, 272-300 mm wide and 260-294 mm in length.

Amoebic encephalitis within Australia.

Granulomatous amoebic encephalitis is a rare but likely under-recognised form of subacute, usually fatal, encephalitis. We present an illustrative case report and literature review of Australian cases, summarising clinical features, diagnostic methods, treatment and outcomes.

SMoRe GloS: An efficient and flexible framework for inferring global sensitivity of agent-based model parameters.

Agent-based models (ABMs) have become essential tools for simulating complex biological, ecological, and social systems where emergent behaviors arise from the interactions among individual agents. Quantifying uncertainty through global sensitivity analysis is crucial for assessing the robustness and reliability of ABM predictions. However, most global sensitivity methods demand substantial computational resources, making them impractical for highly complex models.

Can perpetrators discern survivors from voice?

Research has shown that potential perpetrators and individuals high in psychopathic traits tend to body language cues to target a potential new victim. However, whether targeting occurs also by tending to vocal cues has not been examined. Thus, the role of voice in interpersonal violence merits investigation.