Publications by authors named "K Nilsson-Ekdahl"
Article Synopsis
- The study investigates the role of ficolin-3 in Systemic Lupus Erythematosus (SLE), highlighting its significance in the lectin pathway of the complement system, which has been less explored compared to the classical pathway.
- Analysis of serum samples from SLE patients and genetic variants showed that higher ficolin-3 activity correlates with specific SLE symptoms, including hematological issues and the presence of autoantibodies.
- The findings suggest that ficolin-3 is an important factor in SLE pathogenesis, potentially offering insights into how the lectin pathway contributes to disease manifestations and autoantibody production.
Background: Several studies have shown the importance of the complement and coagulation systems in the pathogenesis of asthma.
Objectives: We explored whether we could detect differentially abundant complement and coagulation proteins in the samples obtained from the small airway lining fluid by collection of exhaled particles in patients with asthma and whether these proteins are associated with small airway dysfunction and asthma control.
Method: Exhaled particles were obtained from 20 subjects with asthma and 10 healthy controls (HC) with the PExA method and analysed with the SOMAscan proteomics platform.
The complement system plays a crucial role in host defense, homeostasis, and tissue regeneration and bridges the innate and the adaptive immune systems. Although the genetic variants in complement C2 (c.839_849+17del; p.
View Article and Find Full Text PDFBackground: Surface compatibility with blood is critical both for scientific investigations on hemostasis and clinical applications. Regarding in vitro and ex vivo investigations, minimal alteration in physiological hemostasis is of particular importance to draw reliable conclusions on the human coagulation system. At the same time, artificial coagulation activation must be avoided, which is relevant for the patient, for example to prevent stent graft occlusion.
View Article and Find Full Text PDFThe cellular and fluid phase-innate immune responses of many diseases predominantly involve activated neutrophil granulocytes and complement factors. However, a comparative systematic analysis of the early impact of key soluble complement cleavage products, including anaphylatoxins, on neutrophil granulocyte function is lacking. Neutrophil activity was monitored by flow cytometry regarding cellular (electro-)physiology, cellular activity, and changes in the surface expression of activation markers.
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