Publications by authors named "K Nijran"
Tackling childhood overweight and obesity after the COVID-19 pandemic.
Lancet Child Adolesc Health
October 2021
Objective: To compare commercially available image analysis tools Hermes BRASS and Siemens with clinical assessment in F-Florbetapir PET scans.
Methods: 225 scans were reported by clinicians and quantified using two software packages. Scans were classified into Type A (typical features) or non-Type A (atypical features) for both positive and negative scans.
Objectives: This study investigates the usefulness of quantitative SUVR thresholds on sub types of typical (type A) and atypical (non-type A) positive (Aβ+) and negative (Aβ-) F-florbetapir scans and aims to optimise the thresholds.
Methods: Clinical F-florbetapir scans ( = 100) were categorised by sub type and visual reads were performed independently by three trained readers. Inter-reader agreement and reader-to-reference agreement were measured.
The number of people living with dementia is increasing, but as yet there remains no cure or disease-modifying treatment. This review aims to help readers understand the role of F-FDG PET/CT imaging in the investigation of cognitive impairment and how the advent of amyloid PET/CT imaging may hold the key to radically changing management of the most common form of dementia - Alzheimer's disease. The indications for F-FDG PET/CT and amyloid PET/CT imaging in cognitive impairment are outlined.
View Article and Find Full Text PDFBackground: It is unknown whether lesions in human TB are hypoxic or whether this influences disease pathology. Human TB is characterised by extensive lung destruction driven by host matrix metalloproteinases (MMPs), particularly collagenases such as matrix metalloproteinase-1 (MMP-1).
Methods: We investigated tissue hypoxia in five patients with PET imaging using the tracer [F]-fluoromisonidazole ([F]FMISO) and by immunohistochemistry.