Sensory and motor representations of internalized rhythms in the cerebellum and basal ganglia.

Both the cerebellum and basal ganglia are involved in rhythm processing, but their specific roles remain unclear. During rhythm perception, these areas may be processing purely sensory information, or they may be involved in motor preparation, as periodic stimuli often induce synchronized movements. Previous studies have shown that neurons in the cerebellar dentate nucleus and the caudate nucleus exhibit periodic activity when the animals prepare to respond to the random omission of regularly repeated visual stimuli.

Demonstration of p35 in hairy cell leukemia of Japanese patients.

Using SDS polyacrylamide gel electrophoresis (SDS-PAGE), several coworkers isolated a unique membrane protein that they named p35 from hairy cells of white patients with hairy cell leukemia. In the current study using a similar technique, p35 was identified in hairy cells from 2 of 4 Japanese patients with hairy cell leukemia. Further, p35 was immunoprecipitated from the leukemic membrane proteins of one of these two Japanese patients with an anti-hairy cell serum prepared against hairy cells of a typical white patient.