Superior preclinical efficacy of co-treatment with BRG1/BRM and FLT3 inhibitor against AML cells with FLT3 mutations.

Although treatment with standard frontline therapies, including a FLT3 inhibitor (FLT3i) reduces AML burden and achieves clinical remissions, most patients with AML with FLT3 mutation relapse due to therapy-resistant stem/progenitor cells. The core ATPases, BRG1 (SMARCA4) and BRM (SMARCA2) of the canonical (c) BAF (BRG1/BRM-associated factor) complex is a dependency in AML cells, including those harboring FLT3 mutations. We have previously reported that treatment with FHD-286, a BRG1/BRM ATPases inhibitor, induces differentiation and loss of viability of AML stem/progenitor cells.

A Review on Energy Management System for Grid-Connected Utility-Scale Renewable Hybrid Power Plants.

In recent years, renewable hybrid power plants (HPPs) have experienced rapid expansion. Energy management systems (EMSs) are vital to these facilities, helping maximize economic returns for owners and shaping operational strategies across various time scales. However, a comprehensive review of advancements in this field is still lacking.

Impact of Cochlear Implant on the Quality of Life in Post Lingual Deafened Adult Population in Tertiary Care Centre.

Unlabelled: In India, 7-8% of the population is affected by post lingual deafness, which can lead to job dissatisfaction, depression, social withdrawal, and educational challenges. Despite the benefits, cochlear implantation in Northern India remains underutilized. This study examines the impact of cochlear implants on post lingual deafness, along with their etiology and indications.

MicroRNAs in lung cancer: their role in tumor progression, biomarkers, diagnostic, prognostic, and therapeutic relevance.

MicroRNAs (miRNAs) are a class of small non-coding RNAs which are associated with post-transcriptional regulation of gene expression. Dysfunction or aberrant expression of miRNAs is predominant in various malignancies including lung cancer. Lung cancer is one of the commonest causes of cancer-related death worldwide, with a five-year survival of only 10-20%.

Photoconductivity Switching in Semiconducting Two-Dimensional Crystals via Molecular Tetris.

Two-dimensional organic materials are mainly constructed by using orthogonal anisotropic connectivity of covalent bonding and π-π stacking. The noncovalent connectivity between building blocks is presumed to be too delicate to stabilize the two-dimensional (2D) layers. Contrary to this assumption, we constructed graphite-like 2D layered material by utilizing pure noncovalent connectivity, i.