Publications by authors named "K Nicole Crowder"

Article Synopsis
  • Metastases originate from specific subsets of cancer cells that spread from the primary tumor, with their ability to thrive in new locations being impacted by genetic and epigenetic changes.
  • Certain types of cancers tend to consistently metastasize to particular tissues, indicating that the characteristics of the primary tumor play a role in determining metastatic sites.
  • Research shows that both primary and metastatic pancreatic tumors share metabolic traits and that cancer cells prefer to grow in their original site rather than in new metastatic locations, highlighting the influence of the tumor's tissue of origin on its growth and spread.
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Antibody effector functions including antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP) are mediated through the interaction of the antibody Fc region with Fcγ receptors present on immune cells. Several approaches have been used to modulate antibody Fc-Fcγ interactions with the goal of driving an effective antitumor immune response, including Fc point mutations and glycan modifications. However, robust antibody-Fcγ engagement and immune cell binding of Fc-enhanced antibodies in the periphery can lead to the unwanted induction of systemic cytokine release and other dose-limiting infusion-related reactions.

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The tumor microenvironment is a determinant of cancer progression and therapeutic efficacy, with nutrient availability playing an important role. Although it is established that the local abundance of specific nutrients defines the metabolic parameters for tumor growth, the factors guiding nutrient availability in tumor compared to normal tissue and blood remain poorly understood. To define these factors in renal cell carcinoma (RCC), we performed quantitative metabolomic and comprehensive lipidomic analyses of tumor interstitial fluid (TIF), adjacent normal kidney interstitial fluid (KIF), and plasma samples collected from patients.

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Housing affordability is a growing challenge for households in the United States and other developed countries. Prolonged exposure to housing cost burden can have damaging effects on households, and, in particular, children. These burdens can exacerbate parental stress, reduce investments in children and expose households to greater neighborhood disadvantage.

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