Publications by authors named "K Neumayer"
Background: The Children's Intracranial Injury Decision Aid (CHIIDA) was developed to predict which patients with complicated mild traumatic brain injury (cmTBI; GCS ≥13 with depressed skull fracture or intracranial injury) would achieve the composite outcome of neurosurgical intervention, intubation >24 h, or death. The study also explored the CHIIDA as a triage tool to determine need for PICU care. The purpose of this study is to externally validate the CHIIDA and assess its effects on PICU triage.
View Article and Find Full Text PDFThe BRAF gene and the TERT promoter are among the most frequently altered genomic loci in low-grade (LGG) and high-grade-glioma (HGG), respectively. The coexistence of BRAF and TERT promoter aberrations characterizes a subset of aggressive glioma. Therefore, we investigated interactions between those alterations in malignant glioma.
View Article and Find Full Text PDFA future global pandemic is likely to occur and planning for the care of critically ill children is less robust than that for adults. This review covers the current state of federal and regional resources for pediatric care in pandemics, a strategy for pandemic preparation in pediatric intensive care units and regions focusing on stuff, space, staff and systems, considerations in developing surge capacity and triage protocols, special circumstances such as highly infectious and highly lethal pandemics, and a discussion of ethics in the setting of pediatric critical care in a pandemic.
View Article and Find Full Text PDFArticle Synopsis
- Meningiomas are mostly non-cancerous tumors, but some can become more dangerous over time. Researchers studied how mutations in a specific gene (the TERT promoter) affect these tumors and patient survival.* -
- They looked at 128 tissue samples from 110 patients, finding TERT promoter mutations in about 5.5% of those samples, which was linked to increased telomerase activity and poorer survival rates for patients.* -
- The study suggests that while TERT promoter mutations make meningiomas more aggressive and shorten survival, they might also help develop new treatments for patients with these tumors.*
Article Synopsis
- - Ependymomas are a type of brain tumor in children that often reoccur even after complete surgical removal, and recent studies have identified different molecular subgroups of these tumors, though their aggressive behavior is not fully understood.
- - This study investigated the role of telomerase reactivation, a common cancer mechanism for avoiding aging, in specific pediatric ependymoma subgroups by analyzing various molecular markers like telomerase activity and genetic variations in a patient cohort.
- - Results showed that certain subgroups (particularly PF-EPN-A and ST-EPN-RELA) experienced significant telomerase activation linked to poorer survival rates, highlighting the importance of telomerase in disease progression and revealing potential molecular pathways influencing this process.