Concrete with a High Content of End-of-Life Tire Materials for Flexural Strengthening of Reinforced Concrete Structures.

This research investigates the performance of Steel Fiber Reinforced Rubberized Concrete (SFRRC) that incorporates high volumes of End-of-life tire materials, (i.e., both rubber particles and recycled tire steel fibers) in strengthening existing reinforced concrete (RC) beams.

The design and development of deferiprone (L1) and other iron chelators for clinical use: targeting methods and application prospects.

Iron is essential for all human cells as well as neoplastic cells and invading microbes. Natural and synthetic iron chelators could affect biological processes involving iron and other metal ions in health and disease states. Iron overload is the most common metal toxicity condition worldwide.

Benefits and risks of deferiprone in iron overload in Thalassaemia and other conditions: comparison of epidemiological and therapeutic aspects with deferoxamine.

Deferiprone is the only orally active iron-chelating drug to be used therapeutically in conditions of transfusional iron overload. It is an orphan drug designed and developed primarily by academic initiatives for the treatment of iron overload in thalassaemia, which is endemic in the Mediterranean, Middle East and South East Asia and is considered an orphan disease in the European Union and North America. Deferiprone has been used in several other iron or other metal imbalance conditions and has prospects of wider clinical applications.