Publications by authors named "K Natarajaseenivasan"
Indwelling intrauterine contraceptive devices (IUDs) have surfaces that facilitate the attachment of spp., creating a suitable environment for biofilm formation. Due to this, vulvovaginal candidiasis (VVC) is frequently linked to IUD usage, necessitating the prompt removal of these devices for effective treatment.
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- Calcium uptake by mitochondria is crucial for managing energy levels, cell death, and calcium signals, and is primarily facilitated by the Mitochondrial Calcium Uniporter (MCU).
- Although the regulation of MCU by MICUs is well-established, the impact of divalent cations like magnesium (Mg) on MCU activity is less understood.
- The study identified Mrs2 as the mammalian mitochondrial Mg channel and demonstrated that lower matrix magnesium levels lead to increased MCU activity and calcium overload, ultimately contributing to cell death during tissue injury.
The aberrant increase in cardio-metabolic diseases over the past couple of decades has drawn researchers' attention to explore and unveil the novel mechanisms implicated in cardiometabolic diseases. Recent evidence disclosed that the derangement of cardiac energy substrate metabolism plays a predominant role in the development and progression of chronic cardiometabolic diseases. Hence, in-depth comprehension of the novel molecular mechanisms behind impaired cardiac metabolism-mediated diseases is crucial to expand treatment strategies.
View Article and Find Full Text PDFDisturbances in lipid metabolism in the CNS contribute to neurodegeneration and cognitive impairments. Through tight metabolic coupling, astrocytes provide energy to neurons by delivering lactate and cholesterol and by taking up and processing neuron-derived peroxidated fatty acids (pFA). Disruption of CNS lipid homeostasis is observed in people who use cocaine and in several neurodegenerative disorders, including HIV.
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