Publications by authors named "K Nandy"
Listeriolysin O (LLO) is a potent membrane-damaging pore-forming toxin (PFT) secreted by the bacterial pathogen . LLO belongs to the family of cholesterol-dependent cytolysins (CDCs), which specifically target cholesterol-containing cell membranes to form oligomeric pores and induce membrane damage. CDCs, including LLO, harbor designated pore-forming motifs.
View Article and Find Full Text PDFBackground: Undifferentiated embryonic cell transcription factor 1 (UTF1) is predominantly expressed in pluripotent stem cells and plays a vital role in embryonic development and pluripotency maintenance. Despite its established importance in murine models, the role of UTF1 on human induced pluripotent stem cells (iPSCs) has not been comprehensively studied.
Methods: This study utilized CRISPR/Cas9 gene editing to create UTF1 knockout in human fibroblasts and iPSCs.
Introduction: Transarterial chemoembolization (TACE) has an established role in advanced HCC. The present study evaluates the role of TACE as a neoadjuvant modality in the management of intermediate HCC [Hong Kong Liver Cancer (HKLC) stage IIB].
Materials And Methods: A retrospective analysis of HCC patients treated between January 2010 and August 2022 was performed.
Article Synopsis
- Extra-ampullary duodenal adenocarcinoma is a rare cancer, and this study examined the long-term outcomes and survival factors in patients who underwent surgery for it.
- The analysis included 59 patients, primarily males aged around 60, with most tumors located in the second part of the duodenum, and followed them for a median of 32 months post-surgery.
- Key findings revealed that factors like having clear surgical margins, the type of adenocarcinoma, and the lymph node ratio significantly impacted overall survival rates, while the effectiveness of adjuvant chemotherapy is still uncertain.