Continued midazolam versus diphenhydramine in difficult-to-sedate patients: a randomized double-blind trial.

Background And Aims: Current guidelines recommend diphenhydramine in patients undergoing endoscopy who are not adequately sedated with a benzodiazepine and opioid combination. Because this practice has not been adequately assessed, we performed a randomized, double-blind trial comparing diphenhydramine with continued midazolam in such patients.

Methods: Patients undergoing elective colonoscopy with moderate sedation were eligible.

Cost analysis of objective resident cataract surgery assessments.

Purpose: To compare 8 ophthalmology resident surgical training tools to determine which is most cost effective.

Setting: University of Rochester Medical Center, Rochester, New York, USA.

Design: Retrospective evaluation of technology.

Interpretation of urine drug testing results in patients using transdermal buprenorphine preparations for the treatment of chronic noncancer pain.

Objective: To determine whether the prevailing liquid chromatography and tandem mass spectroscopy assay (LC-MS/MS) assay designed to monitor buprenorphine compliance of the sublingual formulation used in the substance abuse treatment setting can be extrapolated to the transdermal formulation used in the chronic pain treatment setting, which is 1000-fold less concentrated.

Design: Retrospective chart review.

Subjects: Self-reported compliant patients using the transdermal or sublingual formulations of buprenorhphine.

Neuroimaging of neurocutaneous diseases.

An in-depth knowledge of the imaging characteristics of the common neurocutaneous diseases (NCD) described in this article will help neurologists understand the screening imaging modalities in these patients. The future of neuroimaging is geared towards developing and refining magnetic resonance imaging (MRI) sequences. The detection of tumors in NCD has greatly improved with availability of high-field strength 3T MRI machines.