Publications by authors named "K Nalik-Iwaniak"
Article Synopsis
- Urotoxicity from cyclophosphamide and ifosfamide can impair kidney and bladder function, prompting a study on the effectiveness of acetylcysteine as a protective agent.
- Acetylcysteine treatment did not significantly alter blood parameters but reduced urinary markers of kidney injury and improved bladder histopathology in rats with induced cystitis.
- The findings indicate that acetylcysteine may offer uroprotective benefits and reduce renal dysfunction, suggesting a potential role in protecting the kidneys during cyclophosphamide or ifosfamide therapy.
Unlabelled: The standard pharmacotherapy of benign prostatic hyperplasia (BPH) may also alleviate potential kidney dysfunction resulting from the development of obstructive uropathy in the course of BPH.
Aim: The aim of study was to evaluate the effect of treatment with α-1- adrenolytic agent (tamsulosin) and 5-α-reductase inhibitor (finasteride) on renal function in rats.
Materials And Methods: Four groups of rats were studied: 1 - controls, 2 - rats with metoclopramide-induced hyperprolactinemia BPH model, 3 - rats with BPH treated with tamsulosin, 4 - rats with BPH treated with finasteride.
Background: Disturbances in pancreatic microcirculation, beginning with vasoconstriction, are crucial in early pancreatitis and progression to necrotizing pancreatitis. Thus, vascular-targeted treatment aiming to restore a sufficient level of microcirculation through vasodilation would possibly reduce the severity of pancreatitis. Lidocaine is an anti-arrhythmic and local anesthetic drug, which also acts as a vasodilator at higher concentrations.
View Article and Find Full Text PDFThe administration of cyclophosphamide (CP) is associated with the risk of developing cystitis as well as kidney injury. The aim of the study was to verify the uroprotective effect of N-acetylcysteine (NAC), as well as the evaluation of renal function in the experimental model of acute CP-induced cystitis. Rats from group 1 received intraperitoneally only a single dose of 200 mg/kg b.
View Article and Find Full Text PDFIntroduction: Ifosfamide (IF) is a cytostatic that exhibits adverse nephrotoxic properties. Clinically, IF-induced nephrotoxicity takes various forms, depending on applied dose and length of treatment.
Objectives: The aim of the study was to evaluate the two proteins: osteopontin (OP) and fatty acid binding protein (FABP), as markers of kidney function in rats treated with ifosfamide.