Publications by authors named "K Nakamaru"
This biomarker study explored HER2 expression levels and immune cell characteristics that may affect response to T-DXd using tumor tissue samples collected from clinical trial participants. The results suggest that HER2 expression levels and tumor characteristics before the initiation of T-DXd may correlate with the efficacy of the drug.
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- This study evaluated the effects of preoperative endoscopic ultrasound-guided tissue acquisition (EUS-TA) on patients with resectable or borderline resectable pancreatic cancer.
- Data from 153 patients showed no significant differences in overall survival or positive peritoneal lavage cytology between those who underwent EUS-TA and those who did not.
- The findings suggest that EUS-TA does not negatively affect postoperative survival or the rates of positive cytology in pancreatic cancer surgeries.
Although nanoliposomal irinotecan combined with 5-fluorouracil and leucovorin (nal-IRI+5-FU/LV) has been used to treat first-line resistant unresectable pancreatic cancer, the efficacy and safety data among the elderly remain limited. We retrospectively analyzed clinical outcomes among elderly patients. Patients treated with nal-IRI+5-FU/LV were assigned to the elderly (≥75 years) and non-elderly (<75 years) groups.
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- The study investigated how neoadjuvant chemotherapy (NAC) affects gut microbiota in patients with resectable pancreatic ductal adenocarcinoma (PDAC).
- Using stool samples from 20 patients, researchers analyzed microbiota changes before and after treatment, finding no significant differences in overall diversity.
- Notably, they discovered a significant decrease in the Actinobacteria phylum post-NAC and an association between lower levels of Bifidobacterium and poorer tumor response to the chemotherapy.
Objective Steroid pulse therapy is a regimen involving the intravenous administration of supra-pharmacological doses of corticosteroids in the short term. It is used to treat various inflammatory and autoimmune conditions. However, the strengths and limitations of steroid pulse therapy for induction of remission in type 1 autoimmune pancreatitis (AIP) are unknown.
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