Genotype-specific and light dependence of polyamine uptake and metabolism in wheat plants.

Information about genotype- or light-dependent differences in the dynamics of polyamine uptake and metabolism is limited in plants. In the present study, these differences were characterised in putrescine-treated three wheat genotypes grown on hydroponic solution in growth chamber. Putrescine treatment induced putrescine accumulation especially in the roots; however, distinct variations indicated different regulation strategies among the genotypes.

Efficacy of ubrogepant and atogepant in males and females with migraine: A secondary analysis of randomized clinical trials.

Background: Published evidence supporting efficacy of calcitonin gene-related peptide receptor antagonists as acute migraine treatments in males is limited.

Methods: To fill the gap, we present male and female data from four ubrogepant and four atogepant randomized, double-blind, placebo-controlled trials for acute and preventive treatment of migraine, respectively. Acute outcomes included 2-h pain freedom and absence of most bothersome symptom (co-primary; headache-phase randomized, double-blind, placebo-controlled trials); absence of moderate-to-severe headache within 24 h (primary; prodrome randomized, double-blind, placebo-controlled trial).

Integration of precision medicine into the dental care setting.

This narrative review aims to discuss the incorporation of novel medical concepts and tools into dental practice, with the goal of improving early diagnosis and exploring new personalized treatment options for oral pathologies, such as caries and periodontitis. Preventative dental approaches concentrate on the timely detection of oral infections and the integration of biomarker analysis to recognize pathogenic changes at early stage of disease. Likewise, periodic monitoring after the treatment is relevant to ensure the balance in the oral biofilms and prevent relapse.

The Enzyme Effect: Broadening the Horizon of MS Optimization to Nontryptic Digestion in Proteomics.

In recent years, alternative enzymes with varied specificities have gained importance in MS-based bottom-up proteomics, offering orthogonal information about biological samples and advantages in certain applications. However, most mass spectrometric workflows are optimized for tryptic digests. This raises the questions of whether enzyme specificity impacts mass spectrometry and if current methods for nontryptic digests are suboptimal.