Adult hypophosphatasia presenting with recurrent acute joint pain.

Summary: Hypophosphatasia (HPP) is a genetic disorder due to pathological variants in ALPL, the gene encoding tissue-nonspecific alkaline phosphatase (ALP). HPP is typically associated with bone-related symptoms, such as bone deformity, fractures and bone pain in children, but can appear in adults with symptoms resembling arthritis. A 22-year-old male experienced repeated and severe sudden attacks of joint pain in the elbows and knees.

A luminous and young galaxy at = 12.33 revealed by a JWST/MIRI detection of Hα and [O iii].

The James Webb Space Telescope has discovered a surprising population of bright galaxies in the very early Universe (≲500 Myr after the Big Bang) that is hard to explain with conventional galaxy-formation models and whose physical properties are not fully understood. Insight into their internal physics is best captured through nebular lines, but at these early epochs, the brightest of these spectral features are redshifted into the mid-infrared and remain elusive. Using the mid-infrared instrument onboard the James Webb Space Telescope, here we present a detection of Hα and doubly ionized oxygen ([O iii] 4959,5007 Å) from the bright, ultra-high-redshift galaxy candidate GHZ2/GLASS-z12.

Surgical and Long-term Outcomes of Combined Organ Resection for Esophageal Cancer Invading Adjacent Organs: Experience of 90 Consecutive Cases.

Objective: To evaluate the feasibility of and long-term survival with combined organ resection for esophageal cancer (EC).

Background: The optimal treatment strategy for EC that is invading adjacent organs is not established.

Methods: Ninety patients with EC invading adjacent organs who underwent combined organ resection after induction treatments during 2003-2023 in our institute were eligible for the study.

Remote Activation Catalysis: Interparticle Hydrogen Spillover-Assisted Cumene Synthesis from Propane and Benzene.

Hydrogen spillover, particularly when involving "interparticle" hydrogen spillover, offers a unique opportunity to enhance catalytic efficiency by remote activation of surface acidity. Building on this concept, this study aims to investigate physically mixed alumina-supported platinum nanoparticles (Pt/AlO) and zirconia-supported tungsten oxide (WO/ZrO) in promoting the direct synthesis of cumene from benzene and propane at 300 °C. The reaction with Pt/AlO alone afforded propylene as the only product, indicating the successive reaction route of Pt-catalyzed dehydrogenation of propane, followed by acid-catalyzed alkylation.