Three-dimensional single-pixel imaging using a fractal superconducting nanowire single-photon detector.

Faint-light imaging plays an important role in applications including fluorescence-lifetime microscopy and remote sensing. Superconducting nanowire single-photon detectors (SNSPDs) outperform other single-photon detectors in terms of comprehensive performance, however, large-format SNSPD imagers with many pixels remain an outstanding technological challenge. Here, as an alternative route, we use a multimode-fiber-coupled fractal SNSPD as the light-sensing element to perform three-dimensional single-pixel imaging at the wavelength of 1560 nm.

CD146 promotes resistance of NSCLC brain metastases to pemetrexed via the NF-κB signaling pathway.

Introduction: Pemetrexed is a first line drug for brain metastases from lung cancer, either as monotherapy or combined with other drugs. The frequent occurrence of initial and acquired resistance to pemetrexed results in limited treatment effectiveness in brain metastases. CD146 was recently found to play important roles in chemoresistance and tumor progression.

Circular Single-Stranded DNA-Based Artificial Nanoviruses Mitigate Colorectal Cancer Development.

Colorectal cancer (CRC) remains a significant global health challenge, underscoring the need for innovative therapeutic strategies. Oncogenic miRNAs (oncomiRs) play a significant biological role in the initiation and progression of colorectal cancer. Inspired by the cooperative mechanisms of plant nanovirus, which employ multiple circular single-stranded DNA (CssDNA) genomes, it is hypothesized that the development and delivery of CssDNA to target oncomiRs would achieve therapeutic benefits in CRC.

Odor impact patterns and health risks of various enterprises in the rubber product manufacturing industry.

The rubber product manufacturing (RPM) industry generates a large number of odor complaints because persistent and distinctive volatile compounds are released during the associated processes. Such compounds represent a nuisance and may pose health risks to nearby residents. Extensive monitoring and sampling identified 146 volatile organic compounds (VOCs) from 20 enterprises across 6 subcategories of the RPM industry.

Taming Highly Enolizable Aldehydes via Enzyme Catalysis for Enantiocomplementary Construction of β-Hydroxyphosphonates.

Taming highly enolizable aldehydes for catalytic asymmetric C-C coupling with nucleophiles remains an elusive challenge compared to widely explored simple alkyl or aryl aldehydes. Herein, we use ThDP-dependent enzymes to realize the direct C-C coupling of highly enolizable 2-phosphonate aldehydes with in situ-generated dynamically reversible nucleophiles (acyl anions). Unlike NHC-mediated reactions that yield complex mixtures of multiple adducts, our enzymatic process selectively produces biologically active β-hydroxy phosphonates with high yields (up to 95%) and excellent enantioselectivities (up to 99% ee).