Publications by authors named "K N Sood"
Long-Acting Injectable Antipsychotics in Adolescents with Bipolar Disorder.
J Child Adolesc Psychopharmacol
January 2025
Bipolar disorder often begins in adolescence or early adulthood, characterized by recurrent manic episodes that can lead to neurodegenerative brain changes and functional decline. While several oral second-generation antipsychotics are Food and Drug Administration (FDA)-approved for mania, adherence to maintenance treatment is frequently poor due to factors such as anosognosia, cognitive dysfunction, impulsivity, side effects aversion, and substance use. Long-acting injectable (LAI) antipsychotics, approved for adults with bipolar mania or schizoaffective disorder (bipolar type), offer a potential solution for adolescents with similar conditions.
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- Open nanoshells, or 'semi shells', have special plasmonic properties due to their asymmetric structure and are typically made using complex methods, but this study introduces a simpler one-step process for creating them.
- The newly fabricated PEGylated semi-shells show strong localized surface plasmon resonance under near-infrared light and remain effective even after being preserved for long periods, demonstrating safety in mice with no toxic effects post intravenous injection.
- In animal trials, these PEGylated semi-shells exhibited high photothermal efficiency, leading to complete eradication of primary breast tumors without affecting critical organs, and resulted in a 75% survival rate without complications for up to 90 days
Autologous serum protein stabilized silver quantum clusters as host-specific antibacterial agents.
Nanomedicine (Lond)
September 2024
Article Synopsis
- The study aimed to create silver quantum clusters stabilized by serum proteins from different hosts (bovine, human, and murine) to evaluate their safety and effectiveness as antibacterial agents.
- Ag-QCNS showed strong antibacterial properties, particularly against antibiotic-resistant strains, and demonstrated high biocompatibility and hemocompatibility in preclinical tests with mice over a 28-day period.
- The antibacterial mechanism involved the generation of reactive oxygen species (ROS) and damage to bacterial membranes, suggesting that Ag-QCNS could serve as a promising next-generation treatment option for antibiotic resistance.
Background: Intravascular lithotripsy (IVL) is a novel technique increasingly used for plaque modification and endovascular revascularization in patients with severe calcification and peripheral artery disease. However, much of the available literature on IVL is focused on its use in coronary arteries, with relatively limited data on non-coronary artery use.
Aim: To analyze the safety and efficacy of current IVL use in non-coronary artery lesions, as reported in case reports and case series.