Whole-brain mapping in adult zebrafish and identification of the functional brain network underlying the novel tank test.

Zebrafish have gained prominence as a model organism in neuroscience over the past several decades, generating key insight into the development and functioning of the vertebrate brain. However, techniques for whole brain mapping in adult stage zebrafish are lacking. Here, we describe a pipeline built using open-source tools for whole-brain activity mapping in adult zebrafish.

Safety and Performance of the MOZEC Sirolimus-Eluting Coronary Balloon in the Treatment of Stenotic Coronary Artery Lesions: A Real-World, Multicenter, Post-Marketing Surveillance Study.

Background: Drug-eluting balloons, surface-coated with antiproliferative agents such as sirolimus or paclitaxel, have emerged as an alternative therapeutic option for coronary stenosis. This study evaluated safety and effectiveness of the MOZEC sirolimus-eluting percutaneous transluminal coronary angioplasty (PTCA) balloon dilation catheter (Meril Life Sciences Pvt. Ltd.

Early postoperative conjunctival complications leading to exposure of surgically implanted CorNeat EverPatch devices.

Purpose: To compare the early exposure and surgical revision rates between a new synthetic tissue substitute (CorNeat EverPatch) with that of human donor cornea following placement onto the scleral surface during ophthalmic surgery, and to study the biomaterial properties of the synthetic patch material.

Design: Retrospective comparison study; biomaterial analyses of new and explanted synthetic patch material.

Patients: All consecutive patients who underwent ophthalmic surgery with implantation of the CorNeat EverPatch at the Wilmer Eye Institute (occurring from February to August 2024) and a comparison group who underwent ophthalmic surgery with implantation of irradiated donor cornea, matched 1:2 with patients receiving EverPatch for age, type of glaucoma, and surgeon.

Safety and efficacy of immune checkpoint therapy for the treatment of patients with cardiac metastasis: a multicenter international retrospective study.

Background: Data on the safety profiles and clinical outcomes of patients with solid tumors and cardiac metastasis treated with immune checkpoint inhibitors (ICIs) are limited.

Methods: This is an international multicenter retrospective study of patients with cancer and cardiac metastasis at baseline. Patients who had received ≥1 dose of ICI were included.

A retrospective study of 5S behaviours of Physical Activity (PA) among suburban Mumbai population with Type 2 Diabetes Mellitus (T2DM).

Background: T2DM is a chronic metabolic disorder to manage the same lifestyle modification is cornerstone. In 2022, the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) published a consensus report targeting the management of Type 2 Diabetes Mellitus (T2DM), which emphasised the importance of regular aerobic and resistance exercise. Both forms of physical activity (PA) can improve blood glucose, HbA1C levels, flexibility and balance.