Positive inotropic effect of tyrosine, histidine, and tryptophan in experiments on isolated human myocardium.

Experiments on myocardial strips isolated from the right auricular myocardium of patients with heart failure showed that tyrosine, histidine, and tryptophan increased the amplitude of electrically stimulated contractions. The nature of this effect and clinical implications are discussed.

[Influence of the human blood serum on contractility and beta-adrenoreactyvity of the isolated human myocardium].

On strips of the isolated myocardium of right hearts auriculum of the 43 patients with ischemic illness of heart and 9 patients with heart diseases of various ethyology at statement venous canule during aorto-coronary shunting, estimated influence of adrenaline (10(-9)-10(-4) g/ml) on amplitude caused by electrostimulus (1H, 5ms, 25-30 V) contractions, and also inotropic and adrenomodulation activity of serum blood (in dilution 1 : 10000, 1: 1000, 1 : 500, 1: 100, 1 : 50, 1: 10 and 1 : 5) nonpregnant women. Direct dependence of amplitude of contraction on size of fraction of of blood emission on Teyholts is revealed. It means, that strips of right auriculum myocardium reflect contractility of a left ventriculum myocardium.