Publications by authors named "K N Ganapathy"
Article Synopsis
- Targeted integration (TI) in CHO cell lines is a method used for protein expression, but the effect of epigenetic modifications on these cells hasn't been thoroughly investigated.
- This study focused on analyzing various TI clones with identical transgene copy numbers but different levels of protein expression and found that chromatin accessibility, rather than histone modifications, plays a crucial role in influencing transcription efficiency.
- Attempts to enhance protein production by modifying histone profiles at the CMV promoters did not yield significant improvements, suggesting that increasing chromatin accessibility is key for boosting mRNA transcription and overall productivity in TI cell lines.
Article Synopsis
- Patients with diabetes on dialysis face fluctuating glucose levels and a higher risk of low blood sugar, leading experts to recommend continuous glucose monitoring (CGM) for better management.
- A review of clinical trials found two key studies showing significant improvements in glycaemic control when using CGM, including reductions in average glucose levels and HbA1c.
- Overall, the evidence suggests that CGM can effectively enhance blood sugar management in diabetic patients undergoing dialysis without increasing the risk of hypoglycaemia.
Yakshagana is an India's traditional folk theatre musical dance drama. The purpose of the study is to profile audiological characteristics and document hearing-related symptoms in Yakshagana artists. A cross-sectional study was performed on 96 Yakshagana artists.
View Article and Find Full Text PDFIntroduction: Rational drug prescribing skills of interns remain bleak despite clinical pharmacology training during their second year, warranting the need for further training. This study was designed to evaluate the effectiveness of a short-structured learner-centric training program using the World Health Organization (WHO) guide to good prescribing in improving interns' knowledge of rational drug use and their rational drug prescribing skills.
Methods: This quasi-experimental study was implemented at a tertiary care teaching hospital in South India.
Background: Injectable contraceptives (IC) provide a highly effective, reversible method of preventing conception, yet discontinuation rates are high. Health workers play a crucial role in the successful implementation of family welfare services. Adding up the basket of choices without knowing the community's needs can lead to poor utilization of services.
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