Publications by authors named "K N Ching"
Alcohol use attenuates successful smoking cessation. We examined the feasibility, acceptability, and preliminary efficacy of a brief alcohol intervention in smokers. In this two-arm, assessor-blinded randomized controlled trial, we randomized 100 daily smokers (82.
View Article and Find Full Text PDFCell shape is crucial to cell function, particularly in neurons. The cross-sectional diameter, also known as caliber, of axons and dendrites is an important parameter of neuron shape, best appreciated for its influence on the speed of action potential propagation. Most studies of axon caliber focus on cell-wide regulation and assume that caliber is static.
View Article and Find Full Text PDFSystematic Automated Population-Based Surveillance to Improve Outcomes in Primary Cutaneous Melanoma.
J Prim Care Community Health
December 2024
Importance: Patients with a primary cutaneous melanoma (PCM) are at increased risk of developing a second primary melanoma (SPM). Earlier stage at diagnosis is associated with better 5-year mortality, yet low compliance with recommended follow-up after treatment for PCM and high rates of patients lost to follow-up are reported in the literature. Strategies to enhance population-based surveillance for SPM have not been well described.
View Article and Find Full Text PDFArticle Synopsis
- Metastatic breast cancer (MBC) is a severe and often fatal form of breast cancer linked to over 90% of cancer deaths, with the role of tolerogenic dendritic cells (tolDCs) in its rapid progression still unclear.
- The study uses bioinformatics to analyze gene expression data from MBC and tolDCs, identifying 529 upregulated and 367 downregulated common differentially expressed genes (DEGs) that are connected to the disease.
- Among the 23 hub genes identified, 5 (3 upregulated: ISG15, OAS2, RSAD2; 2 downregulated: eEF2, PPARG) are significant for their correlation to MBC and may serve as potential therapeutic
Article Synopsis
- Hydrogels are advantageous for creating flexible sensors due to their soft texture and adjustable chemical properties, although challenges remain in achieving the right combination of mechanical and conductive traits for practical use.
- A new type of hydrogel sensor, named PAM/BA-Ag@PDA, is developed by polymerizing acrylamide with dynamic crosslinked silver-modified polydopamine nanoparticles, enhancing its strength, conductivity, and self-healing capabilities.
- This hydrogel functions effectively as a strain sensor, showing good sensitivity, rapid response time, and stability while being able to adhere to skin to monitor various movements, making it suitable for wearable healthcare applications.*