Publications by authors named "K N Avery"
Background: Oesophago-gastric cancer surgery negatively affects quality of life with a high postoperative symptom burden. Several conditions that may be diagnosed and treated after surgery are recognised. However, consensus regarding their definition and management is lacking.
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- Variably Protease Sensitive Prionopathy (VPSPr) is a rare, fatal human prion disease that differs from other prion diseases like Creutzfeldt-Jakob disease (CJD), particularly in the sensitivity of its prion proteins to digestion by proteinase.
- The disease is characterized by distinctive protein fragments (23, 17, and 7 kDa) that arise after digestion, especially notable in cases with the codon 129 VV genotype, where a unique 7 kDa fragment can be harder to identify with traditional methods.
- Researchers have found that using capillary electrophoresis (CE) offers a more sensitive and reproducible approach for detecting and analyzing these prion proteins, allowing for
Integration of bioprinting advances and biomechanical strategies forlung modelling.
Biofabrication
November 2024
The recent occurrence of the Covid-19 pandemic and frequent wildfires have worsened pulmonary diseases and raised the urgent need for investigating host-pathogen interactions and advancing drug and vaccine therapies. Historically, research and experimental studies have relied on two-dimensional cell culture dishes and/or animal models, which suffer from physiological differences from the human lung. More recently, there has been investigation into the use of lung-on-a-chip models and organoids, while the use of bioprinting technologies has also emerged to fabricate three-dimensional constructs or lung models with enhanced physiological relevance.
View Article and Find Full Text PDFT-cell activation is a multistep process requiring T-cell receptor engagement by peptide-major histocompatibility complexes (Signal 1) coupled with CD28-mediated costimulation (Signal 2). Tumors typically lack expression of CD28 ligands, so tumor-specific Signal 1 (e.g.
View Article and Find Full Text PDFBackground: Tumor heterogeneity is a main contributor of resistance to anti-cancer targeted agents though it has proven difficult to study. Unfortunately, model systems to functionally characterize and mechanistically study dynamic responses to treatment across coexisting subpopulations of cancer cells remain a missing need in oncology.
Methods: Using single cell cloning and expansion techniques, we established monoclonal cell subpopulations (MCPs) from a commercially available epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer cell line.