Publications by authors named "K N Aswin"
The ultraviolet (UV) radiation triggers a pigmentation response in human skin, wherein, melanocytes rapidly activate divergent maturation and proliferation programs. Using single-cell sequencing, we demonstrate that these 2 programs are segregated in distinct subpopulations in melanocytes of human and zebrafish skin. The coexistence of these 2 cell states in cultured melanocytes suggests possible cell autonomy.
View Article and Find Full Text PDFPurpose: Detecting increased intracranial pressure early in pediatric patients is essential, as early initiation of therapy prevents morbidity and mortality. The objective of this study was to determine the diagnostic accuracy of the optic nerve sheath diameter (ONSD) measured via ultrasound for the prediction of increased intracranial pressure.
Methods: Four databases, namely, PubMed, EMBASE, Scopus, and CINAHL, were searched for this systematic review and meta-analysis.
Background Thoracic trauma accounts for 20-25% of all traumas and is the third most frequent cause of death, after abdominal injury and head trauma. In the Emergency Department (ED), shifting an unstable patient to the X-ray room for detecting pneumothorax and hemothorax is always risky and bedside X-ray causes radiation exposure not only to the particular patient but also to the surrounding patients in a congested and busy ED. This can be avoided by using bedside ultrasonography (USG) as the initial imaging modality in chest trauma patients.
View Article and Find Full Text PDFtechniques offer a fast, accurate, reliable, and economical approach to studying the molecular interactions between compounds and proteins. In this study, our main aim is to use techniques as a rational approach for the prediction of the molecular drug targets for luteolin against . Multi-target molecular docking, 100 nanoseconds (ns) molecular dynamics (MD) simulations, and Molecular Mechanics-Generalized Born Surface Area (MM-GBSA) binding free energy calculations were carried out for luteolin against dihydrofolate reductase thymidylate synthase (DHFR-TS), dihydroorotate dehydrogenase (DHODH), and falcipain-2.
View Article and Find Full Text PDFArticle Synopsis
- The debate over simulated patient mortality in healthcare training centers on whether it enhances learning or deceives students, with some experts advocating for the stress of a death scenario to create a more realistic experience.
- A systematic review of six studies involving 384 learners found that simulated patient mortality significantly increased stress levels compared to survival scenarios, with a pooled mean difference for anxiety and stress of 0.63.
- Three out of five studies indicated that simulated mortality helped improve knowledge retention, but responses varied among learners, suggesting that while some thrive under stress, others may find it detrimental unless properly addressed during debriefing.