Publications by authors named "K N'Guessan"
Article Synopsis
- The study aimed to assess the effectiveness (sensitivity and specificity) of various diagnostic tests for childhood pulmonary tuberculosis (CPTB) using latent class analysis, given the lack of definitive reference standards.
- Conducted in the Ivory Coast, Madagascar, and Cameroon with 1,165 children suspected of having CPTB, multiple tests were evaluated, including smear microscopy, culture, and Xpert on different sample types.
- Results indicated that while smear microscopy was very specific, it had low sensitivity across all sample types; Xpert showed better sensitivity, particularly in gastric and nasopharyngeal aspirates, suggesting a potentially effective diagnostic strategy for CPTB.
Systemic vaccination of macaques with V1-deleted (ΔV1) envelope immunogens reduce the risk of SIV acquisition by approximately 60%, with protective roles played by V2-specific ADCC and envelope-specific mucosal IL-17NKp44 innate lymphoid cells (ILCs). We investigated whether increased mucosal responses to V2 benefit vaccine efficacy by delivering oral nanoparticles (NPs) that release V2-scaffolded on Typhoid Toxin B (TTB) to the large intestine. Strikingly, mucosal immunization of male macaques abrogated vaccine efficacy with control TTB or empty NPs, but vaccine efficacy of up to 47.
View Article and Find Full Text PDFThe objective of this study was to investigate the effects on laying performance, egg quality traits, color, and composition of supplementing a white corn-based diet with leaf flour. Three hundred 32-week-old hens were distributed to 30 pens of 10 hens each and allocated to six dietary treatments (five replicates per treatment) for 13 weeks. Two control groups of 50 hens received one of either diet Y, based on yellow corn, or diet W, based on white corn.
View Article and Find Full Text PDFArticle Synopsis
- The ATLAS program distributed approximately 380,000 HIV self-testing kits to high-risk populations in Côte d'Ivoire, Mali, and Senegal between 2019-2021 to improve HIV diagnosis and treatment coverage.
- A deterministic compartmental model was used to estimate the impacts of the ATLAS program and future scale-up of HIV self-testing on HIV diagnoses, treatment initiation, incidence, and related mortality among key populations.
- The model predicted that ATLAS could result in around 1,500 additional HIV diagnoses across the three countries during 2019-2021, significantly contributing to increased awareness and potential treatment for HIV.
Objectives: To estimate the epidemiological impact of past HIV interventions and the magnitude and contribution of undiagnosed HIV among different risk groups on new HIV acquisitions in Côte d'Ivoire, Mali and Senegal.
Design: HIV transmission dynamic models among the overall population and key populations [female sex workers (FSW), their clients, and MSM].
Methods: Models were independently parameterized and calibrated for each set of country-specific demographic, behavioural, and epidemiological data.