Real-World Safety, Tolerability and Effectiveness of Nintedanib in Patients with Idiopathic Pulmonary Fibrosis: Final Report of Post-marketing Surveillance in Japan.

Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial pneumonia, which is characterised by progressive worsening of dyspnoea and lung function. Nintedanib treatment is recommended to slow IPF disease progression. The aim of this post-marketing surveillance (PMS) study was to evaluate the safety and effectiveness of nintedanib over 24 months in patients with IPF in a real-world setting in Japan.

Case Report: Countermeasures Against Heat and Coronavirus for Japanese Athletes at the Tokyo 2020 Olympics and Paralympic Games.

The Tokyo 2020 Olympics and Paralympic Games were held in the hottest environment in the history of the games. Additionally, the worldwide coronavirus disease 2019 (COVID-19) pandemic necessitated daily polymerase chain reaction (PCR) testing during the games, wearing a mask became mandatory publicly, and it was an unheard and unique Olympic with no spectators. Heat acclimation, hydration, and body cooling are essential for safe and high-performance activities in hot environments.

Comparison of the effects of high and low levels of solar radiations on exercise capacity in hot outdoor environments.

Background: High solar radiation from the sun in the heat outdoor may be impaired exercise capacity. This study aimed to compare the effects of different levels of solar radiation on exercise capacity and evaluate skin temperature responses in the heat.

Methods: Seven male participants performed cycling exercise at 60% of their maximal oxygen uptake until volitional exhaustion in hot outdoor environments (approximately 33-35°C, 40-50% relative humidity) under both clear sky (high solar radiation trial: 1062±50 W/m) and under thick clouds (low solar radiation trial: 438±52 W/m).

Cooling during short-term heat acclimation enhances aerobic capacity but not sweat capacity.

To characterize the adaptive responses to short-term heat acclimation (HA) training with repeated-sprint exercises and to determine the effects of ice slurry ingestion during HA on aerobic capacity and adaptations. Seven physically active males completed two 5 consecutive day interventions in a randomized cross-over design. Participants performed approximately 80-min intermittent repeated-sprints using a cycling ergometer including break-time and half time in 36.

In-play optimal cooling for outdoor match-play tennis in the heat.

The purpose of this study was to compare the efficacy of four cooling interventions used for reducing physiological and perceptual strain and improving exercise performance during outdoor match-play tennis in the heat. Eight competitive tennis players played four counter-balanced simulated outdoor matches in the heat (WBGT: 28.4-32.