Publications by authors named "K Moriarty"
Article Synopsis
- Wolverines in North America have seen a reduction in their distribution due to human activities during the 19th and 20th centuries, leading to their threatened status in the US and special concern status in Canada.
- A study collected 882 genetic samples to analyze landscape connectivity factors, focusing on terrain complexity, human disturbance, forest configuration, and climate across a vast region of southwestern Canada and northwestern US.
- Findings showed that human disturbance negatively affects wolverine genetic connectivity, while forest cover and snow persistence help maintain genetic diversity, which can inform future conservation management efforts.
Article Synopsis
- A randomized controlled trial was conducted with 201 bilingual patients from underserved populations to compare telephone and in-person genetic counseling models for cancer.* -
- Primary outcomes measured included genetics knowledge, visit satisfaction, and counseling completion rates, with no significant differences found between the two counseling methods.* -
- While telephone counseling led to a higher rate of informed choices about genetic testing (52.5% vs. 39.0%), it also resulted in lower completion rates for tests (74% vs. 100%), indicating that although it's comparable, further investigation is needed regarding these disparities.*
In the last three decades, gene therapy has demonstrated significant progress. Over 700 active investigational new drug (IND) applications have been reported. Research on in utero gene therapy has advanced, but ethical and safety concerns persist.
View Article and Find Full Text PDFObjective: Disease severity scores, or endpoints, are routinely measured during Randomized Controlled Trials (RCTs) to closely monitor the effect of treatment. In real-world clinical practice, although a larger set of patients is observed, the specific RCT endpoints are often not captured, which makes it hard to utilize real-world data (RWD) to evaluate drug efficacy in larger populations.
Methods: To overcome this challenge, we developed an ensemble technique which learns proxy models of disease endpoints in RWD.
Women with primary mitral insufficiency have a smaller regurgitant volume at the same regurgitant fraction than men. We hypothesized that normalizing regurgitant volume with left ventricular end-diastolic volume or allometric scaling would eliminate the difference in regurgitant volume between women and men. The study cohort consisted of 101 patients with mitral valve prolapse undergoing cardiac MRI.
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