Publications by authors named "K Moran"
Article Synopsis
- - Juvenile male hamsters exposed to chronic social stress showed increased appetite, weight gain, and larger fat pads, indicating heightened obesity risk.
- - The study aimed to investigate changes in food hoarding behaviors and orexin/hypocretin signaling in these hamsters under social stress conditions.
- - Results confirmed previous findings on overeating and obesity, showing some correlation patterns between orexin innervation and appetite/metabolism, suggesting specific brain changes related to chronic social stress.
Background: The number of older people with unmet health care and support needs is increasing substantially due to the challenges facing health care systems worldwide. There are potentially great benefits to using the Internet of Things coupled with artificial intelligence to support independent living and the measurement of health risks, thus improving quality of life for the older adult population. Taking a co-design approach has the potential to ensure that these technological solutions are developed to address specific user needs and requirements.
View Article and Find Full Text PDFBIVV003 is a gene-edited autologous cell therapy in clinical development for the potential treatment of sickle cell disease (SCD). Hematopoietic stem cells (HSC) are genetically modified with mRNA encoding zinc finger nucleases (ZFN) that target and disrupt a specific regulatory GATAA motif in the BCL11A erythroid enhancer to reactivate fetal hemoglobin (HbF). We characterized ZFN-edited HSC from healthy donors and donors with SCD.
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- * A survey of 144 HAE patients showed that those receiving lanadelumab experienced fewer attacks and reported a better quality of life compared to those on other long-term therapies.
- * The findings indicate that patients treated with lanadelumab not only had lower attack frequency but also faced a lower symptomatic impact, suggesting it may be a more effective treatment option.