SGLT2 inhibitors activate pantothenate kinase in the human heart.

Inhibitors of sodium glucose cotransporter-2 (SGLT2i) demonstrate strong symptomatic and mortality benefits in the treatment of heart failure but appear to do so independently of SGLT2. The relevant pharmacologic target of SGLT2i remains unclear. We show here that SGLT2i directly activate pantothenate kinase 1 (PANK1), the rate-limiting enzyme that initiates the conversion of pantothenate (vitamin B5) to coenzyme-A (CoA), an obligate co-factor for all major pathways of fuel use in the heart.

Exploring biophysical links of catch rate from mid-water trawl fishery in the north-west coast of India, Eastern Arabian Sea: A remote sensing approach.

Fish frequently shift their distribution ranges as a result of changes in preferred environmental factors. Knowledge on distribution of fish in relation to their environmental optima is crucial for improving the understanding of fishing grounds and planning sustainable exploitation. This study investigated the monthly variability in environmental factors impacting the catch rate and the spatio-temporal distribution patterns of fish along northwest coast of India (NWCI) from 2017 to 2019.

Insights into the divergent evolution of the oceanic squid Sthenoteuthis oualaniensis (Cephalopoda: Ommastrephidae) from the Indian Ocean.

Sthenoteuthis oualaniensis is known for its complex population structure with three major transoceanic forms (viz. middle-sized, dwarf, and giant forms) whose taxonomic status has been disputed for decades. This integrated taxonomic study examines these prevenient morphotypes gathered on cruises in the Indian Ocean to ascertain their status in the evolutionary history of the species.

Correction: Metric-based vs peer-reviewed evaluation of a research output: Lesson learnt from UK's national research assessment exercise.

[This corrects the article DOI: 10.1371/journal.pone.

Artificial DnaJ Protein for protein production and conformational diseases.

For secreted proteins, proper protein folding is essential not only for biological function but also for secretion itself. Proteins with folding problems are trapped in the endoplasmic reticulum (ER) and are eventually degraded in the cytoplasm. In this study, we exploited co-expression of an artificial fusion protein, based on the sequence of a DnaJ protein, which could interact as co-chaperones in the Hsp70-based protein-folding system, with target recombinant secreted proteins to enhance their production and secretion.