Publications by authors named "K Mizoguchi"
Article Synopsis
- Statins are drugs that lower cholesterol and have anti-cancer effects by inhibiting a key enzyme in cholesterol production.
- Research shows that the effectiveness of statins varies in different cancer cells, potentially linked to the presence of E-cadherin, which may act as a marker for statin sensitivity.
- Comparing gene expressions and metabolite levels in lung cancer cell lines revealed that statin-sensitive cells have lower cholesterol synthesis gene expression and reduced levels of related metabolites, indicating that these cells might have a limited capacity for cholesterol production and storage when treated with atorvastatin.
Article Synopsis
- - The study investigates the use of IMP3 immunohistochemistry (IHC) as a diagnostic tool for primary diffuse large B-cell lymphoma of the central nervous system (CNS-DLBCL), which is challenging to diagnose due to limited biopsy material.
- - Results showed strong IMP3 expression in 100% of CNS-DLBCL samples, while it was also present in 88.2% of other DLBCLs, but not in inflammatory brain diseases.
- - While IMP3 IHC can help distinguish CNS-DLBCL in cases with limited tumor cells, most cases can be diagnosed without it, indicating that it serves as a supportive diagnostic technique rather than a primary one.
Article Synopsis
- - The study reveals that myogenic stem satellite cell activator HGF experiences nitration due to peroxynitrite, leading to its diminished binding to the receptor c-met, which disrupts muscle health as we age.
- - A specific rat anti-HGF monoclonal antibody, 1H41C10, effectively protects HGF from nitration at critical tyrosine sites (Y198 and Y250), maintaining its function to activate satellite cells.
- - The findings suggest that 1H41C10 could be significant in developing treatments for age-related muscle loss and conditions like sarcopenia by preventing HGF dysfunction.
Dedifferentiated liposarcoma (DDLPS) is a non-lipogenic sarcoma, generally arising from well-differentiated liposarcoma (WDLPS), although it can develop de novo. DDLPS tumors rarely trans-differentiate into non-adipose mesenchymal tissues; however, the latter lack notable variety and mostly show striated muscle or osteogenic/chondrogenic differentiation. Here, we report a case of DDLPS that contained numerous atypical vessels.
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