Publications by authors named "K Miyanishi"
A 65-year-old man with hepatocellular carcinoma and lung metastasis was treated with a combination of atezolizumab and bevacizumab. Subsequently, the patient developed fever and new liver lesions, which were considered to indicate a pseudoprogression. Despite this, the treatment was continued.
View Article and Find Full Text PDFBackground/aim: Soft tissue sarcoma (STS) is a mesenchymal tumor affecting multiple organs in dogs. Previous studies identified activation of the phosphatidylinositol-3 kinase (PI3K)/protein kinase B (PKB, AKT) pathway in canine STS cell lines and clinical samples, but the underlying mechanism remains unclear. This study investigated PTEN loss, PIK3CA mutation, and EGFR over-expression as potential drivers of PI3K/AKT pathway activation in STS.
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- Peptides are crucial for many biological processes, leading to increased interest in tracking their metabolism in living organisms.
- Dissolution-dynamic nuclear polarization (d-DNP) enhances nuclear magnetic resonance (NMR) sensitivity, allowing researchers to gather metabolic and physiological data in real-time.
- This study reveals the successful in vivo detection of metabolic changes in hyperpolarized C-oligopeptides, showing significant alterations in C-glutathione in mouse kidneys affected by acute kidney injury.
Article Synopsis
- Ultrafast stimuli can create stable states of matter that can't be achieved under normal conditions, highlighting the need to understand the relationship between ultrafast processes and these states.
- The study uses advanced optical and X-ray techniques to observe how a polar vortex supercrystal forms in a specially designed material when it's excited by light, demonstrating various phases in just a few picoseconds.
- Over time, fluctuations in the structure of the supercrystal are gradually eliminated, leading to the stable formation of a single vortex supercrystal phase, with theoretical models supporting these observations.